Dr. Yang joined Med-X Research Institute as an Associate Dean and KC Wong Endowed Professor, Director of the Institute of rehabilitation engineering, Shanghai Jiao Tong University from 2008. Dr. Yang is also serve as a Board member of China Stroke Association (CSA); Vice chairman of the Society of Chinese cerebral blood flow and metabolism, CSA; Vice chairman of the translational Neuroscience Committee, Chinese Society of Translational Research Hospital; a Board member of Synchrotron Radiation Committee, the Chinese Society of Physics. Dr. Yang is the associate editor of Stroke and Vascular Neurology, Frontiers in Aging Neuroscience, Aging and Disease; Editor board members of Stroke, CNS Neuroscience & Therapeutics, Neural Regeneration Research, Neuroimmunology and Neuroinflammation, Chinese Journal of Cerebrovascular Diseases, Stroke magazine, and Chinese modern nerve disease, etc.

The major achievements of Dr. Yang include: 1) developed middle cerebral artery occlusion and reperfusion model in mice; 2) developed intra-cerebral hemorrhage model in rat; 3) pioneered cerebral vascular malformation model in mice and studied the mechanism of vascular development and lesion; 4) creatively applied gene therapy technology to treat cerebral injury induced by ischemic stroke; 5) creatively took advantage of different growth factors and stem cells in intervention treatment for cerebral ischemic animals; 6) creatively used synchrotron radiation angiography and unique microvascular imaging techniques to study the occurrence and development of cerebrovascular disease in vivo in real time, developed focal angiogenesis and focal microvessel dysplasia model in rodent brain for cerebrovascular study. Dr. Yang is also working on exploring advanced treatment for stroke by taking advantages of neuroimaging, neural rehabilitation, biomaterials, and medical device. 

Dr. Yang awarded NIH grants in USA and many funding from China including the 973 project, Ministry of science and technology of China, Chinese Natural Science Fund (CNSF), Shanghai Science and Technology Commission, and Shanghai Jiao Tong University. Has long been engaged in neurobiology, neurology and neurosurgery, especially cerebral vascular disease of translational research, Dr. Yang has written 12 books including “Operational Neurosurgery”, “Animal Experimental Stroke Neurosurgery”, “Translational Research in Stroke” etc. He has published more than 300 SCI papers, H-index 77, the total impact factor (IF) is more than 1200. Cited references have reached more than 19000 times. He keeps one of the highest cited scholars in the field of medicine in China from this rank system established.

1974-1977 M.B. Shanghai Second Medical University, Shanghai, China

1977-1982 Residency Shanghai Second Medical University, Shanghai, China

1982-1987 MD/PhD Shanghai Medical University, Shanghai, China

1989-1991 Post-doc University of California at San Francisco, CA, USA

1978-1985 Residency, Dept. of Neurosurg., Shanghai Sec. Med. Univ., Shanghai, China

1985-1987 Neurosurgeon, Dept. of Neurosurg., Shanghai Med. Univ., Shanghai, China

1987-1989 Neurosurgeon, Dept. of Neurosurg., Shanghai Med. Univ., Shanghai, China

1991-1992 Visiting Res. Investigator, Sch. of Med., Univ. of Mich., MI, USA

1992-1996 Res. Investigator, Surgery, Sch. of Med., Univ. of Mich., MI, USA

1996-2001 Assis. Res. Scientist, Neurosurgery, Sch. of Med., Univ. of Mich., MI, USA

2001-2006 Asso. Prof., Anesthesia and perioperative care, UCSF, San Francisco, CA, USA

2001-2006 Associate Professor, Neurological Surgery, UCSF, San Francisco, CA, USA

2006-2008 Professor, Anesthesia and perioperative care, UCSF, San Francisco, CA, USA

2001-2008 Professor, Neurological Surgery, UCSF, San Francisco, CA, USA

2008- Professor, Med-X Research Institute, Shanghai, China

2011- Professor, School of Biomedical Engineering, Shanghai, China

Mechanisms of cerebral vascular disease

Ischemic and hemorrhagic stroke therapy

Tracking microRNAs, genes, and stem cells in the brain

Drug therapy, gene therapy, stem cell therapy, and rehabilitation

Applications of synchrotron radiation angiography in studies on neurological disease

Applications of biological materials in neurological diseases

Connectome of brain functions and structures

1987  Second Prize of Sci. and Tech. development award, Chinese Society of Medicine

2010 The Third Prize of Sci. and Tech. award, Shanghai Municipality, China

2013 The second prize of science award, the Ministry of Education, China

2015 The second prize of science award, Shanghai Municipal Government, China

2017 Fellow of the American Institute for Medical and Biological Engineering (AIMBE)

2018 The Best Researcher awards, Chinese Stroke Association

2018 International Fellow of the American Heart Association (FAHA)

2019 The Top Reviewer awards, Society of JCBF&M

• Associate Dean of Med-X Research Institute, SJTU, China
• The Director of Institute of Rehabilitation Engineering, SJTU, China
• Associate Director, the Cerebral Blood Flow and Metabolism Committee, Chinese Stroke Association, China
• Associate director, the Translational Neuroscience Committee, the Chinese Research Hospital Association, China
• Council member of the Synchrotron Radiation Committee, the China Physical Science, China
• Associate editor of Stroke and Vascular Neurology
• Associate editor of Aging and Disease
• Associate editor of Frontiers in Aging Neuroscience
• Editorial board member of Stroke
• Editorial board member of JCBF&M

• Neurobiology for Biomedical Engineering
• Experimental Neurobiology for Biomedical Engineering
• Scientific Writing, Reliability and Ethics

Ongoing Funding

Science and Technology of Commission Shanghai Municipality (PI: Yang, GY)

Number and Period：20JC1411900 (10/20-09/23)

Title：Development of multifunctional molecular imaging probe for tracking human iPS-derived neural progenitor cells and its treatment for brain diseases.

RMB: ¥ 2,000,000

Major Scientific Research and Innovation Project of Shanghai Municipal Education Commission (PI: Yang, GY)

Number and Period：2019-01-07-00-02-E00064 (01/19-12/23)

Title: Research on the mechanism of microglia on ischemic stroke

RMB: ¥ 3,000,000

NSFC (PI: Yang, GY)

Number and Period：81771251 (01/18-12/21)

Title: The molecular mechanism of M1 microglia mediated white matter injury in chronic cerebral ischemia

RMB: ¥ 540,000

National Key Research and Development Program of China (PI: Wang, M)

Number and Period：2016YFC1300602 (09/16-12/21)

Title: screening and validation of biomarkers for small vessel disease

RMB: ¥ 830,000

Role: (Co-PI: Yang GY)

Completed Funding

NSFC (PI: Yang GY)

Number and Period: 81471178 (01/15-12/18)

Title：Mesenchymal stem cells protect blood brain barrier integrity by inhabiting aquaporin-4 after ischemic stroke

RMB: ¥ 850,000

NSFC Joint Research fund for overseas Chinese, Hong Kong and Macao Scholars (PI: Yang GY)

Number and Period: 81428014 (01/15-12/16)

Title：The role and mechanism of pluripotent vascular stem cells in atherosclerosis

RMB: ¥ 200,000

NSFC (PI: Yang GY)

Number and Period: U1232205 (01/13-12/16)

Title：Study on dynamic changes of cerebral microvasculature in living animals after stroke

RMB: ¥ 2,400,000

Science and Technology Commission of Shanghai municipality (PI: Yang, GY)

Number and Period：12X190030021 (01/13-12/16)

Title：The therapeutic effect and mechanism of protecting neurovascular unit and promoting angiogenesis in ischemic stroke

RMB: ¥ 1,000,000

Science and Technology Commission of Shanghai Municipality (PI: Yang GY)

Number and Period: 13140903500 (06/09-09/11)

Title：Establishment of rat thromboembolism model with novel nanoparticles

RMB: ¥ 250,000

973 Program (Director：Shumin Duan；PI: Yang GY)

Number and Period: 2011CB504405 (01/11-08/15)

Title: Role of astrocytes in CNS repair and functional recovery

RMB: ¥ 6,090,000

NSFC (PI: Yang GY)

Number and Period: 81070939 (01/11-12/13)

Title: The mechanisms of endothelial progenitor cell therapy in ischemic brain injury

RMB: ¥ 400,000

973 Program (Director：Lisa Xu；PI：Yang GY)

Number and Period: 2010CB834306 (01/10-12/14)

Title: Biomedical imaging studies based on Shanghai synchrotron radiation facility

RMB: ¥ 1,945,000

NSFC (PI: Yang GY)

Number and Period: 30973097 (01/10-12/12)

Title: Role of Netrin-1 in promoting angiogenesis after ischemic stroke

RMB: ¥ 340,000

Science and Technology Commission of Shanghai Municipality (PI: Yang GY)

Number and Period: 10JC1408100 (10/10-09/12)

Title: Cellular and molecular mechanisms of endothelial progenitor cells mediated stroke repair

RMB: ¥ 300,000

Science and Technology Commission of Shanghai Municipality (PI: Yang GY)

Number and Period: 09140902400 (06/09-09/11)

Title: Standardization of rodent models for ischemic stroke

RMB: ¥ 350,000

Bai Yu Lan Technology Award (PI: Yang GY)

Number and Period: 2009B063 (05/09-05/10)

Title: Application of mesenchymal stem cells in developing nanomaterials for artery graft

RMB: ¥ 30,000

Shanghai Jiao Tong University (PI: Yang GY)

Number and Period: YG08PETZD11 (01/09-12/11)

Title: PET/CT study of ischemic stroke

RMB: ¥ 100,000

NIH/NINDS (Project Director: Young, WL)

Number and Period: PO1 NS044155 (09/03-06/08)

Title: Integrative study of brain vascular malformations

Core C: Laboratory

Role: (PI: Yang GY)

NIH/NINDS (PI: Young WL)

Number and Period: R01 NS27713 (06/05-04/09)

Title: Hemodynamics of cerebral arteriovenous malformations

Role: Investigator (Co-PI: Yang GY)

CIRM (PI: Samuol Pleasure)

Number and Period: RC1-00135-1 (06/07-05/11)

Title: Human stem cell derived oligodendrocytes for treatment of Stroke and MS

Role: (Co-PI: Yang GY)

UCSF, Integrative Research Award (PI: Synthia Mellon) Sandler Program in Basic Sciences Number and Period: (08/06-08/08)

Title: Human stem cell-derived oligodendrocyte lineage in the treatment of ischemic stroke

Role: (Co-PI: Yang GY)

NIH/NINDS (PI: Chen, Y)

Number and Period: R21 NS053943 (06/07-05/11)

Title: Del-1 induces therapeutic cerebral angiogenesis

Role: Co-Investigator (Yang GY)

NIH/NIGMS (PI: Litt, L)

Number and Period: R01 GM034767 (06/04-05/08)

Title: 2D NMR of energy rescue from PARP in brain slice hypoxia

Role: Co-Investigator (Yang GY)

NIH/NINDS (PI: Yang GY)

Number and Period: R01 NS35089-01A1 (01/97-12/00)

Title: The mechanisms of action of IL-1 in ischemic brain

NIH/NINDS (PI: Julian T, Hoff)

Number and Period: RO1 NS17760 (01/92-12/99)

Title: Intracerebral hemorrhage and brain edema

Role: Co-Investigator (Yang GY)

NIH/NINDS (PI: Yang GY)

Number and Period: R21 NS045123 (06/03-05/05)

Title: Transgenic murine model of brain vascular malformation

NIH/NINDS (PI: Yang GY)

Number and Period: R21 NS050668 (07/05-04/07)

Title: BBB protection during treatment of transient ischemia

1) Ma Y, Li Y, Jiang L, Wang L, Jiang Z, Wang Y, Zhang Z, Yang GY. Macrophage Depletion Reduced Brain Injury following Middle Cerebral Artery Occlusion in Mice. J Neuroinflammation. 2016;13:38.

2) Zeng LL, He XS, Liu JR, Zheng CB, Wang YT, Yang GY. Lentivirus-Mediated Overexpression of MicroRNA-210 Improves Long-Term Outcomes after Focal Cerebral Ischemia in Mice. CNS Neurosci. Ther. 2016;22:961-969.

3) Ma Y, Wang J, Wang Y, Yang GY. The Biphasic Function of Microglia in Ischemic

Stroke. Prog Neurobiol. 2017;157:247-272. Review.

4) Cai H, Ma Y, Jiang L, Mu Z, Jiang Z, Chen X, Wang Y, Yang GY, Zhang Z. Hypoxia Response Element-Regulated MMP-9 Promotes Neurological Recovery via Glial Scar Degradation and Angiogenesis in Delayed Stroke. Mol. Ther. 2017;25:1448-1459.

5) Huang J, Song J, Qu M, Wang Y, An Q, Song Y, Yan W, Wang B, Wang X, Zhang S, Chen X, Zhao B, Liu P, Xu T, Zhang Z, Greenberg DA, Wang Y, Gao P, Zhu W, Yang GY. MicroRNA-137 and microRNA-195* Inhibit Vasculogenesis in Brain Arteriovenous Malformations. Ann Neurol. 2017;82:371-384.

6) Cheng Z, Wang L, Qu M, Liang H, Li W, Li Y, Deng L, Zhang Z, Yang GY. Mesenchymal Stem Cells Attenuate Blood-brain Barrier Leakage After Cerebral Ischemia in Mice. J Neuroinflammation. 2018;15:135.

7) He X, Liu Y, Lin X, Yuan F, Long D, Zhang Z, Wang Y, Xuan A, Yang GY. Netrin-1 Attenuates Brain Injury after Middle Cerebral Artery Occlusion via Downregulation of Astrocyte Activation in Mice. J Neuroinflammation. 2018;15:268.

8) Qin C, Zhou P, Wang L, Mamtilahun M, Li W, Zhang Z, Yang GY, Wang Y. Dl-3-N-butylphthalide Attenuates Ischemic Reperfusion injury by Improving the Function of Cerebral Artery and Circulation. J Cereb Blood Flow Metab. 2019;39:2011-2021.

9) Wang L, Zhou P, Mu Z, Lin X, Jiang L, Cheng Z, Luo L, Xu Z, Geng J, Wang Y, Zhang Z, Yang GY. Dynamic Detection of Thrombolysis in Embolic Stroke Rats by Synchrotron Radiation Angiography. Transl Stroke Res. 2019;10:695-704.

10) Song Y, Li Z, He T, Qu M, Jiang L, Li W, Shi X, Pan J, Zhang L, Wang Y, Zhang Z, Tang Y, Yang GY. M2 Microglia-derived Exosomes Protect the Mouse Brain from Ischemia-Reperfusion Injury via Exosomal miR-124. Theranostics. 2019;9:2910-2923.

11) Wang J, Lin X, Mu Z, Shen F, Zhang L, Xie Q, Tang Y, Wang Y, Zhang Z, Yang GY. Rapamycin Increases Collateral Circulation in Rodent Brain after Focal Ischemia as Detected by Multiple Modality Dynamic Imaging. Theranostics. 2019;9:4923-4934.

12) Pan J, Qu M, Li Y, Wang L, Zhang L, Wang Y, Tang Y, Tian HL, Zhang Z, Yang GY. MicroRNA-126-3p/-5p Overexpression Attenuates Blood-Brain Barrier Disruption in a Mouse Model of Middle Cerebral Artery Occlusion. Stroke. 2020;51:619-627.

13) Zhang LY, Pan J, Mamtilahun M, Zhu Y, Wang L, Venkatesh A, Shi R, Tu X, Jin K, Wang Y, Zhang Z, Yang GY. Microglia Exacerbate White Matter Injury via Complement C3/C3aR Pathway after Hypoperfusion. Theranostics. 2020;10:74-90. 

· A multi position upper and lower limb rehabilitation robot

· Inventors: Fang J, Xie L, Yang GY, Zhang Y

· Patent number: ZL 201410217852.6

· A kind of rehabilitation air cushion shoes imitating walking dynamic mode 

· ZL 2014 1 0374533.6 

· Inventors: Fang J, Xie L, Yang GY

Patent number:  ZL 201410374533.6