Hao HE

Associate professor

Email : haohe@sjtu.edu.cn

Office address : Med-X 209


Dr. Hao He is an tenured associate professor in School of Biomedical Engineering, Shanghai Jiao Tong University. He got the B.S. from the University of Science and Technology of China in 2006 and the PhD degree in the Chinese University of Hong Kong in 2010 respectively. Since 2011, he worked as an associate professor in the Ultrafast laser Laboratory in Tianjin University. Since 2014, he joined the School of Biomedical Engineering in SJTU. His research focuses on the precise stimulation and modulation of cellular signaling and functions by femtosecond lasers and applications of such technologies in vivo. His research is supported by the NSFC funding, and awarded as the JSPS oversea fellowship. He was invited as the Global Science Course (GSC) Lectureship.

Education background


2002-2006 Bachelor - the University of Science and Technology of China 

2006-2010 Ph.D. – the Chinese University of Hong Kong

Work Experience


2011-2014, College of Precision Instrument and Optoelectronics Engineering, Tianjin University

2014-present, School of Biomedical Engineering, Shanghai Jiao Tong University

Areas of Research Interests


Honors And Awards


Science and Technology Progress Award by Ministry of Education, First Class-Theory of Heuristic Search (1987);

Boards, Advisory Committees, Professional Organizations


Member of Technical Advisory Board, Microsoft Research Asia (1997-present);



BI428 Biophysics

X082009 Biomedical Photonics

Research Projects

1. 2021.1-2023.12. National Natural Science Foundation of China, 62022056, Femtosecond Biophotonics, 1,200,000 RMB. Principal Investigator

2. 2021.1-2023.12. National Natural Science Foundation of China, 92054105, The investigation of the interaction network and calcium modulation of endoplasmic reticulum, mitochondria, and nucleus. 800,000 RMB. Principal Investigator

3. 2020/01-2023/12. National Natural Science Foundation of China, 81571719, The investigation of nuclear Ca2+ modulated of cells by femtosecond-laser stimulation. 630,000 RMB. Principal Investigator

4. 2017/01-2020/12. National Natural Science Foundation of China, 81661168014, Investigation of technology and mechanism of in/ex vivo stem-cell differentiation by femtosecond laser. 850,000 RMB. Principal Investigator

5. 2016/01-2019/12. National Natural Science Foundation of China, 81571719, Investigation of stem-cell differentiation induced by ultra-fast laser. 580,000 RMB. Principal Investigator

6. 2012/01-2014/12. National Natural Science Foundation of China, Investigation on regulation of gene expression by cellular calcium modulated by femtosecond laser. 61108080. 360,000 RMB Principal Investigator


Selected Publications

1. Pan Cheng, Xiaoying Tian, Wanyi Tang, Juan Cheng, Jin Bao, Haipeng Wang, Sisi Zheng, Youjun Wang, Xunbin Wei, Tunan Chen, Hua Feng, Tian Xue, Hao He,* Direct control of store-operated calcium channels by ultrafast laser. Cell Research. 2020 (IF=20.6) https://doi.org/10.1038/s41422-020-00463-9

2. Hao He*, S Li, S Wang, M Hu, Y Cao, and C Wang. Manipulation of cellular light from green fluorescent protein by a femtosecond laser. Nature Photonics 6, 651-656 (2012). See also “Biophotonics: The slow fade of cell fluorescence”, Nature Photonics 6, 641–643 (2012)

3. Hao He, Keiichi Nakagawa, Yisen Wang, Yoichiro Hosokawa, Keisuke Goda. Mechanism for microtsunami-induced intercellular mechanosignalling. Nature Photonics 9, 623 (2015)

4. Wang, Shaoyang Liu, Yaohui Zhang, Dapeng Chen, Shih-chi Kong, Siu-Kai Minglie, Hu Cao, Youjia He, Hao*. Photoactivation of Extracellular-Signal-Regulated Kinase Signaling in Target Cells by Femtosecond Laser. Laser & Photonics Reviews. 12, 1700137. (2018) Cover story. 

5. Hao He, K.T. Chan, S.K. Kong, R.K.Y. Lee. All-optical human cell fusion by a fiber femtosecond laser. Applied Physics Letters 93, 163901 (2008).  See also “Femtosecond Fusion,” Nature Photonics 2, 709 (2008).