Xinyu CHAI


Dr. Xinyu Chai is full Professor of School of Biomedical Engineering. He received his Ph.D. degree in biomedical engineering from the Xi’an Jiaotong University in 1998. From 1999 to 2001, Dr. Chai conducted postdoctoral research at Shanghai Jiao Tong University (SJTU). He then worked as Associate- and full Professor of School of Life Sciences and Biotechnology at SJTU (2001-2011). Currently he is Full Professor in School of Biomedical Engineering of the SJTU. He presided over the 7 projects of the NSFC Program, 863 Program, 973 Program, the National Key Technology R&D Program and a number of enterprises research and development projects. He has published more than 200 peer-reviewed journal articles and conference papers, editor-in-chief of a book and three book chapters, and 10+ China issued patents. He is a member of the editorial board of Interdisciplinary Sciences-Computational Life Sciences and the reviewer of Information Sciences, Journal of Neural Engineering, Artificial Organs, IOVS, et al, a member of ARVO and SPIE.

Education background

1980 - 1984 Bachelor - Zhengzhou University

1988 - 1990 Master - Xi’an Jiaotong University

1995 - 1998 Ph.D. - Xi’an Jiaotong University

Work Experience

2011 - present, Professor, School of Biomedical Engineering, Shanghai Jiao Tong University (SJTU)  

2007 – 2011, Professor, School of Life Sciences and Biotechnology, SJTU

2001 – 2007, Associate Professor, School of Life Sciences and Biotechnology, SJTU

1999 – 2001, Postdoctoral Research Fellow, School of Life Sciences and Biotechnology, SJTU

1991 – 1995, Lecturer, Physical Engineering College, Zhengzhou University

1984 – 1988, Teaching Assistant, Department of Physics, Zhengzhou University,

Areas of Research Interests

Neural engineering and neural prosthetic devices, visual function rehabilitation and visual prosthesis, neural mechanism of electrical stimulation of the visual nervous system, artificial visual information processing & optimization, optic imaging and photoacoustic imaging, artificial intelligence & its applications

Honors And Awards

2018 The Second Prize of National Undergraduate Biomedical Engineering Innovation Design Competition (mentor), the Steering Committee of Biomedical Engineering Education, Ministry of Education, China

2017 Honor in Education, for contributions of 30 years of teaching, Shanghai Municipal Education Commission.

2016 The Third Prize of National Undergraduate Biomedical Engineering Innovation Design Competition (mentor), the Steering Committee of Biomedical Engineering Education, Ministry of Education, China.

2014 The Third Prize of Natural Science Award, for the contribution of “Minimum information requirements and optimization of artificial vision in visual prosthesis”, Shanghai Municipal People's Government.

Boards, Advisory Committees, Professional Organizations

Principle of Medical Instrumentation- BI255 (Spring)

Rehabilitation Engineering of Visual and Auditory Functions: Assistive and Substitutive Technologies - X082001 (Spring)

Research Projects

1. NSFC Program: Research on spatially selective neural modulation of transcorneal electrical stimulation on retina based on sinusoidal temporally interfering electric fields (62073221, PI)
2. NSFC Program: Research on image information optimization strategy and cognitive mechanism in artificial retina prosthesis vision (61773256, PI)
3. NSFC Program: Mechanism of virtual channel by retinal electrical stimulation and its interaction with visual nervous system (61472247, PI)
4. NSFC Program: Minimal information requirement and optimization of artificial vision for retinal prosthesis (61273368, PI)
5. 973 Program of Ministry of Science & Technology of China: Research of information processing and coding theory for visual prosthesis (2011CB7075003, PI)
6. The National Key Technology R&D Program: Technology integration and comprehensive development of a well-off standard township town hospitals (2008BAI65B03, PI)
7. 863 Program/National High-Tech Research and Development Program: Artificial visual prosthesis micro-system based on MEMS technology: (2009AA04Z326, PI)
8. 973 Program/National Key Basic Research Development Program: Research on information processing of visual prosthesis (2011CB707503, PI)
9. NSFC Program:  Investigation of topographical projection from optic nerve to visual cortex by microelectrode array in optic nerve stimulation and visual cortex recording (60871091, PI)
10. NSFC Program: Minimum requirements for visual prosthesis to restore useful vision based on psychophysics (31070895, PI)
11. NSFC Program: Application of bilinear time-frequency analysis method on transient evoked otoacoustic emissions (60671059 PI)
12. 863 Program/National High-Tech Research and Development Program: Key technologies development for artificial retina (2006AA04Z356, Co-PI)
13. 973 Program/National Key Basic Research Development Program: Development of image acquisition and processing system in visual prosthesis (2005CB724303, PI)

Selected Publications
  • Xiaofan Su, Jiahui Guo, Meixuan Zhou, Jianpin Chen, Liming Li, Yao Chen, Xiaohong Sui, Heng Li, Xinyu Chai. Computational modeling of spatially selective retinal stimulation with temporally interfering electric fields. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 29:418-428, 2021.
  • Qing Lyu, Zhuofan Lu, Heng Li, Shirong Qiu, Jiahui Guo, Xiaohong Sui, Pengcheng Sun, Liming Li, Xinyu Chai, and Nigel H Lovell. A three-dimensional microelectrode array to generate virtual electrodes for epiretinal prosthesis based on a modeling study. International Journal of Neural Systems, 30(03)11: 2050006, 2020.
  • Pengcheng Sun, Qian Li, Heng Li, Liqing Di, Xiaofan Su, Jianpin Chen, Hao Zheng, Yao Chen, Chuanqing Zhou*, and Xinyu Chai*. Depth-resolved physiological response of retina to transcorneal electrical stimulation measured with optical coherence tomography. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 27(5):905-915, 2019.
  • Pengcheng Sun,Heng Li, Zhuofan Lu, Xiaofan Su, Zengguang Ma, Jianpin Chen, Liming Li, Chuanqing Zhou, Yao Chen*, Xinyu Chai*. Comparison of cortical responses to the activation of retina by visual stimulation and transcorneal electrical stimulation. Brain Stimulation, 11(4): 667-675, 2018.
  • Heng Li, Yajie Zeng, Zhuofan Lu, Xiaofei Cao, Xiaofan Su, Xiaohong Sui, Jing, Wang and Xinyu Chai. An optimized content-aware image retargeting method: toward expanding the perceived visual field of the high-density retinal prosthesis recipients. Journal of Neural Engineering, 15: 026025, 2018.
  • Heng Li, Tingting Han, Jing Wang, Zhuofan Lu, Xiaofei Cao, Yao Chen, Liming Li, Chuanqing Zhou, Xinyu Chai*. A real-time image optimization strategy based on global saliency detection for artificial retinal prostheses. Information Sciences, 415-416:1-18, 2018
  • Heng Li, Jing Wang, Tingting Han, Yajie Zeng, Han Kan, Xinyu Chai*. Image processing strategies based on saliency segmentation for object recognition under simulated prosthetic vision. Artificial Intelligence in Medicine, 84:64-78, 2018.
  • Zengguang Ma, Pengjia Cao, Pengcheng Sun, Zhuofan Lu, Liming Li, Yao Chen, Xinyu Chai. Negative hemodynamic response without neuronal inhibition investigated by combining optical imaging and electrophysiological recording. Neuroscience Letters, 637:161-167, 2017.
  • Qian Li, Lin Li, Tianhao Yu, Qingliang Zhao, Chuanqing Zhou, and Xinyu Chai. Vascular tree extraction for photoacoustic microscopy and imaging of cat primary visual cortex. Journal of Biophotonics, 10:780-791, 2017.
  • Zengguang Ma, PengJia Cao, PengCheng Sun, Linna Zhao, Liming Li, Shanbao Tong, Yiliang Lu, Yan Yan, Yao Chen*, Xinyu Chai*. Inverted optical intrinsi response accompanied by decreased cerebral blood flow are related to both neuronal inhibition and excitation. Scientific Reports, 6: 21627, 2016. 
  • Jing Wang, Heng Li, Weizhen Fu, Yao Chen, Qing Lyu, Tingting Han, Xinyu Chai. Image processing strategies based on a visual saliency model for object recognition under simulated prosthetic vision, Artificial Organs, 40(1):94-100, 2016.
  • 22. Xun Cao, Xiaohong Sui, Qing Lyu, Liming Li and Xinyu Chai. Effects of different three-dimensional electrodes on epiretinal electrical stimulation by modeling analysis. Journal of NeuroEngineering and Rehabilitation, 12:73, 2015.
  • Zengguang Ma, Pengjia Cao, Pengcheng Sun, Liming Li, Yan Yan, Yiliang Lu, Yao Chen*, and Xinyu Chai*. Optical imaging of visual cortical responses evoked by transcorneal electrical stimulation with different parameters. Investigative Ophthalmology & Visual Science, 55(8): 5320-5331, 2014.
  • Jing Wang, Xiaobei Wu, Yanyu Lu, Hao Wu, Han Kan, Xinyu Chai*. Face recognition in simulated prosthetic vision: face-detection-based image processing strategies. Journal of Neural Engineering, 11(4): 046009, 2014.
  • Jing Wang, Yanyu Lu, Liujun Gu, Chuanqing Zhou, Xinyu Chai*. Moving object recognition under simulated prosthetic vision using background-subtraction-based image processing strategies. Information Sciences, 277:512-524, 2014.

1. Xinyu Chai, Yufeng Xu, Ying Zhao. “Handheld portable otoacoustic emissions analyzer”, China Patent Number: ZL 2006 1 0024502. 3, 2008.
2. Xinyu Chai, Zhaodi WangD, Junyan Wang, Ying Zhao, Xinde Zhu. “Low pressure quaternary-gradient mixing device”, China Patent Number: ZL 2006 1 0024975. 3, 2008.
3. Xinyu Chai, Qiushi Ren, Yang Zhou, Ying Zhao. “RF communication device for the implantable neuro-stimulator”, China Patent Number: ZL 2006 1 0027985. 2, 2010.
4. Xinyu Chai, Ying Zhao, Yukun Tian, Ji Zhao, Qiushi Ren. “Image processing device and strategy for visual prosthesis”, China Patent Number: ZL 2008 1 0034286. X, 2010.
5. Xinyu Chai, Yanyu Lu, Zhumao Zhang, Huwei Liu, Qiushi Ren. “Tactile-vision substitution system based on electrical stimulation”, China Patent Number: ZL 2008 1 0200430. 2, 2010.
6. Xinyu Chai, Jingru Shi, Ying Zhao, Yanyu Lu, Qiushi Ren. “Phosphene generating device and strategy based on simulated prosthetic vision”, China Patent Number: ZL2009 1 0197192.9, 2012.
7. Xinyu Chai, Tianao Li, Zheng Cao, Qiushi Ren. “Automatic impedance test system for flexible thin-film microelectrode array”, China Patent Number: ZL201010132952.0, 2012
8. Xiaohong Sui, Xinyu Chai, Xuejiao Luo, Niansheng Xia, Li Lin. “Preparation method of 3D carbon microelectrode with microfluidic channels drug delivery”, China Patent Number: ZL201110234994.X, 2014.
9. Xinyu Chai, Kaijie Wu, Yun Gu, Xuping Lei. “An image acquisition device for visual prostheses based on eye-tracking”, China Patent Number: ZL201210275805.8, 2014.
10. Kaijie Wu, Xinyu Chai, Lei XP, Yun Gu. “Wireless transmission system and method of vision prosthesis with power adaptive adjustment function”, China Patent Number: ZL201210282827.7, 2015.
11. Xinyu Chai, Chuanqing Zhou, Lin Li. “Photoacoustic imaging signal multiplexing device and method”, China Patent Number: ZL201410836861.3, 2016.
12. Xinyu Chai, Yajie Zeng, Zhuofan Lu. “Auxiliary walking glasses and methods for patients with tubular vision”, China Patent Number: ZL201710365012.8, 2019.