Dr. Yan Guo is an Associate Professor of Institute of Biomedical Engineering at Shanghai Jiao Tong University. She holds bachelor and master degree from Southeast University (1994-2001), and doctor's degree in biochemistry and molecular biology of Shanghai Jiao Tong University (2001-2005). She has worked as a faculty of Shanghai Jiao Tong University since 2005. She is interested in new methods for spatial system biology (especially the methods for spatial genome and spatial transcriptome at single cell resolution), and understanding the molecular mechanism of gastric carcinogenesis and organ development based on spatial system biology methods. She has published 28 research papers and leaded several NSFC grants.

Education background

1994-1998 Bachelor – Southeast University

1998-2001 Master – Southeast University

2001-2005 Ph.D – Shanghai Jiao Tong University

Work Experience

2005-2013 Institute of System Biomedicine, Shanghai Jiao Tong University

2013- , Institute of Biomedical Engineering, Shanghai Jiao Tong University

Areas of Research Interests

Methods for spatial system biology

Gastric carcinogenesis

Gene regulation in organ development

Boards, Advisory Committees, Professional Organizations

Cancer: basic knowledge and progress in clinical diagnosis and treatment – Undergraduate Course (Spring)

Basic Principles of Cancer – Graduate Course (Autumn)

Recent advances in cancer development, diagnosis and treatment – Graduate course (Spring)

Research Projects

1. Construction of three-dimensional single cell atlas and study gene transcription regulatory network of metaplasia tissue in intestinal type gastric cancer; National Natural Science Foundation of China (General Program, 81972909), 550000 yuan

From January 2020 to December 2023

2. Research on gene regulatory network and its key nodes of malignant transformation of chronic gastritis; National Natural Science Foundation of China (Major Program, 91529302), 1 million yuan

From January 2016 to December 2018

3. Study on precise dynamic transcription factor regulatory network of malignant transformation from normal gastric epithelial cells to intestinal metaplasia under uncontrolled inflammation

Funding sources: National Natural Science major research plan cultivation project (project approval No. 91229108), 900000 yuan

From January 2013 to December 2015

4. Establishment of in situ transcriptomics technology for detection of macrophages in breast cancer microenvironment; National Natural Science Youth Fund (30900271), 200000 yuan

From December 2009 to December 2012

Selected Publications
  • Jian Ni*, Chuansheng Hu*, Hua Li, Xinhui Li, Qiong Fu, Daniel M Czajkowsky#, Yan Guo#, Zhifeng Shao, Significant improvement of data quality with simplified SCRB-seq, Acta Biochimica et Biophysica Sinica, 2020, 52(4): 457-459
  • Jiangrong Chen*, Chunchao Zhu*, Chaojie Wang*, Chuansheng Hu, Daniel M Czajkowsky, Yan Guo#, Bingya Liu#, Zhifeng Shao#, Evidence for Heightened Genetic Instability in Precancerous Spasmolytic Polypeptide Expressing Gastric Glands. Journal of Medical Genetics. 2020; 57: 385-388
  • Jiangrong Chen, Chunchao Zhu, Chaojie Wang, Xiaodan Zhang, Jian Ni, Daniel M. Czajkowsky, Bingya Liu#, Yan Guo#, Discovery and genetic characterization of intestinal metaplasia in the Helicobacter felis-infected mouse model of gastric cancer. Acta Biochimica et Biophysica Sinica, 2019, 51(2), 219-222
  • Yan Guo*, Ayuan Huang*, Chuansheng Hu, Yan Zhou, Xiaodan Zhang, Daniel M. Czajkowsky, Jianfang Li, Shidan Cheng, Ruizhe Shen, Jianren Gu, Bingya Liu, Zhifeng Shao, Complex clonal mosaicism within microdissected intestinal metaplastic glands without concurrent gastric cancer, Journal of Medical Genetics. 2016; 53: 643-646
  • Guo Y*, Zhou J*, Huang AY, Li JF, Yan M, Zhu ZG, Zhao XD, Gu JR, Liu BY, Shao ZF, Spatially defined microsatellite analysis reveals extensive genetic mosaicism and clonal complexity in intestinal metaplatic glands, International Journal of Cancer, 2015, 136(12), 2973-2979