Chunfu ZHANG


Email : cfzhang@sjtu.edu.cn

Office address : Room 425, School of Biomedical Engineering, Shanghai Jiao Tong University (Xuhui Campus), 1954 Huanshan Road, Shanghai, 200030


Chunfu Zhang obtained his PhD degree in 2002 from Shanghai Institute of Applied Physics, Chinese Academy of Sciences (ACS). During the next two years, he became Assistant Professor/Associate Professor in Shanghai Institute of Applied Physics of CAS. In 2004, he joined German Cancer Research Center (DKFZ) as a guest scientist. In 2007, he conducted postdoctoral study in UT Southwestern Medical Center. He joined the Med-X Research Institute, Shanghai Jiao Tong University in 2008. Currently he is Professor in School of Biomedical Engineering, SJTU. His research interests include design of multimodal molecular imaging probes for tumor theranostics and developing novel nuclear medicines for clinical translation. He has developed Fe3O4, MnOX, Au and carbon-based nanoprobes to regulate tumor microenvironment to enhance tumor immunotherapy, radiotherapy, photothermal therapy and photodynamic therapy. Using gold nanoclusters as carrier, he has developed tumor specific targeting radiopharmaceuticals. He has published more than 100 peer-reviewed papers, including Advanced Science, ACS Nano, Cancer Research, Biomaterials, Radiology, Advanced Functional Materials.

Education background

1992-1996 Bachelor- Chemistry, Henan Normal University

1996-1999 Master-Physical Chemistry, Henan Normal University

1999-2002 Ph.D.-Nuclear Medicine, Shanghai Institute of Applied Physics, ACS.

Work Experience

2002-2004, Assistant Professor, Shanghai Institute of Applied Physics, CAS

2005-2007, Guest Scientist, Department of Medical Physics, German Cancer Research Center (DKFZ).

2007-2008, Post doctor, UT Southwestern Medical Center.

2009-2015, Associate Professor, Med-X Research Institute, SJTU.

2016-present, Professor, School of Biomedical Engineering, SJTU.

Areas of Research Interests

1. Developing novel molecular imaging nano probes for tumor theranostics.

2. Nuclear medicine for clinical translation (e. g. 68Ga, 177Lu, 90Y, 223Ra).

Boards, Advisory Committees, Professional Organizations

Editorial Board, Nanomedicine: Nanotechnology, Biology and Medicine (2014-present)

Editorial Board, Nano Biomed. Eng. (2016-present).

Selected Publications

1. Yifei Jiang, Qinghe Wu, Mengfei Hou, Wangxi Hai, Min Zhang, Biao Li, Chunfu Zhang*. pH-sensitive gold nanoclusters labeling with radiometallic nuclides for diagnosis and treatment of tumor. Materials Today Bio 2023,19, 100578. https://doi.org/10.1016/j.mtbio.2023.100578.

2. Mengfei Hou, Haiyang Su, Qinghe Wu, Wenshe Sun, Pengli Zhang, Yifei Jiang, Kun Qian,* and Chunfu Zhang*. A Self-Enhancing Nanoreactor Reinforces Radioimmunotherapy by Reprogramming Nutrients and Redox Metabolisms. Adv. Funct. Mater. 2023, 2212510.

3. Pengli Zhang, Qinghe Wu, Jingxing Yang, Mengfei Hou, Benchao Zheng, Jia Xu, Yimin Chai, Liqin Xiong, Chunfu Zhang*. Acta Biomaterialia 2022, 146, 450–464.

4. Qinghe Wu, Mengfei Hou, Pengli Zhang, Yifei Jiang, Meirong Liu, Liqin Xiong, Wangxi Hai, Min Zhang, Xiao Li, Biao Li, Chunfu Zhang*. Self-cascade nanohybrids boost cell ferroptosis stress for tumor radiosensitization therapy. Applied Materials Today, 2022, 29, 101558.

5. Benchao Zheng, Qinghe Wu, Yifei Jiang, Mengfei Hou, Pengli Zhang, Meirong Liu, Lu Zhang, Biao Li, Chunfu Zhang* One-pot synthesis of 68Ga-doped ultrasmall gold nanoclusters for PET/CT imaging of tumors. Materials Science & Engineering C 2021, 128, 112291.

6.Wenshe Sun, Jingxing Yang, Mengfei Hou, Shaowei Xie, Liqin Xiong, Biao Li, and Chunfu Zhang*. A Nano “Immune-Guide” Recruiting Lymphocytes and Modulating the Ratio of Macrophages from Different Origins to Enhance Cancer Immunotherapy. Advanced Functional Materials. 2021, 31(23), 2009116.

7. Shaowei Xie, Wenshe Sun, Chunfu Zhang*, Baijun Dong, Jingxing Yang, Mengfei Hou, Liqin Xiong, Biao Cai, Xuesong Liu, and Wei Xue*. Metabolic Control by Heat Stress Determining Cell Fate to Ferroptosis for Effective Cancer Therapy. ACS Nano 2021, 15, 4, 7179–7194.

8. Jingxing Yang, Mengfei Hou, Wenshe Sun, Qinghe Wu, Jia Xu, Liqin Xiong, Yimin Chai, Yuxin Liu, Meihua Yu, Haolu Wang, Zhi Ping Xu, Xiaowen Liang, and Chunfu Zhang*. Sequential PDT and PTT Using Dual-Modal Single-Walled Carbon Nanohorns Synergistically Promote Systemic Immune Responses against Tumor Metastasis and Relapse. Advanced Science. 2020, 7(16),2001088.

9. Yanlei Liu, Jingxing Yang, Bin Liu, Wen Cao, Jingpu Zhang, Yuming Yang, Lijun Ma, Jesus Martinez de la Fuente, Jie Song, Jian Ni, Chunfu Zhang*, Daxiang Cui*. Human iPS Cells Loaded with MnO2‑Based Nanoprobes for Photodynamic and Simultaneous Enhanced Immunotherapy Against Cancer. Nano-Micro Lett. 2020, 12:127.

10. Lu Zhang, Huilan Su, Haolu Wang, Qian Li, Xiao Li, Chuanqing Zhou, Jia Xu, Yimin Chai, Xiaowen Liang, Liqin Xiong and Chunfu Zhang. Tumor Chemo-Radiotherapy with Rod-Shaped and Spherical Gold Nano Probes: Shape and Active Targeting Both Matter. Theranostics, 2019; 9(7): 1893-1908.