Research Associate

Email : linli92@sjtu.edu.cn

Office address : 207 Med-X institute (Xuhui Campus)

Website : linlab-sjtu.com


Dr. Lin received her B.S. and Ph.D. degrees from Shanghai Jiao Tong University (SJTU) in 2013 and 2018, respectively, and worked as a joint postdoctoral fellow at the University of Illinois at Urbana-Champaign (UIUC) and SJTU from 2018 to 2021. Her current research interests include surface-enhanced Raman scattering as a bioimaging modality for in vivo surgical navigation, or as an optical platform to study biomaterial interfaces. She has developed transmission Raman tomography techniques for three-dimensional in vivo Raman imaging (IVRI). Dr. Lin has received a number of awards, including Shanghai Chenguang (Young scholar) Program (2021), Best Paper Award at IMCO-2019 International Conference (2019), and Best Paper nomination Award at IEEE 3M-Nano conference (2021).

Education background

2009-2013 B.S. – Biomedical Engineering, Shanghai Jiao Tong University

2013-2018 Ph.D. – Biomedical Engineering, Shanghai Jiao Tong University

Work Experience

2018-2020 Joint Postdoctoral Researcher, University of Illinois at Urbana-Champaign (UIUC), USA

2021-present Assistant Professor, Shanghai Jiao Tong University

Areas of Research Interests

Plasmonics and surface-enhanced Raman spectroscopy (SERS)
Design and Synthesis of SERS Nanomaterials
Deep Raman techniques for in vivo detection and imaging
Raman spectroscopy and deep learning-based tumor diagnosis

Honors And Awards

Shanghai Education Municipal “Chen-Guang” Young Scholar Program (2022)
Best Paper Award Nomination, IEEE 3M-Nano Conference (2021)
Best Paper Award, The 9th International Multidisciplinary Conference on Optofluidics (2019)


BME9001, Frontiers of Biomedical Engineering
GE7002, Ethics and Academic Norms of Medicine and Engineering
BME7006, Academic Integrity and Research Ethics (English Class)
BME8201, Spectroscopic Nanomaterials in Biomedical Application

Research Projects

National Science Foundation of China (NSFC), PI, 2024-2027, “Deep Raman techniques for the non-invasive photosafe detection and depth estimation of in vivo lesions”
Shanghai Science and Technology Research Program, co-PI and theme leader, 2021-2023, “Raman fiber-optics and medical microrobot based spectroscopic tumor biopsy”
Shanghai Municipal Chen-guang Program, PI, “Transmission Raman spectroscopy for the non-invasive detection of in vivo lesions”
Shanghai Jiao Tong University Medicine-Engineering Program, co-PI, “Rapid diagnosis of gastric cancer based on Raman fiber-optics system and machine learning algorithms”
National Science Foundation of China (NSFC), PI, 2019-2022, “Enhanced Raman Tags in the Second Near-Infrared Window and Their Tissue Penetration Depth Study”

Selected Publications

1.   Li Lin*, Haoqi He, Ruiyang Xue, Yumin Zhang, Ziwen Wang, Shuming Nie*, Jian Ye*. Direct and quantitative assessments of near‑infrared light attenuation and spectroscopic detection depth in biological tissues using surface‑enhanced Raman scattering. Med-X, 2023, 1, 9.

2.    Zongyu Wu, Binge Deng, Yutong Zhou, Haoqiang Xie, Yumin Zhang, Li Lin*, Jian Ye*. Non-invasive detection, precise localization, and perioperative navigation of in vivo deep lesions using transmission Raman spectroscopy. Advanced Science. 202301721.

3.  Yumin Zhang, Li Lin*, Jian Ye*. A rapid and universal method for depth estimation of lesions in heterogeneous tissues via photosafe ratiometric transmission Raman spectroscopy. View, 2023, 20230022.

4.    Yumin Zhang, Ruoyu Chen, Fugang Liu, Peng Miao, Li Lin*, and Jian Ye*. In Vivo Surface-Enhanced Transmission Raman Spectroscopy under Maximum Permissible Exposure: Toward Photosafe Detection of Deep-Seated Tumors. Small Methods, 2023, 7(2), 2201334.

5.    Li Lin, Ruiyang Xue, Shuming Nie. "Surface-enhanced Raman scattering (SERS) nanoparticles for biodiagnostics, bioimaging, and spectroscopy-guided cancer surgery", In: Reference Module in Materials Science and Materials Engineering, Elsevier, 2022. (Invited Book Chapter)

6.   Haoqi He, Yumin Zhang, Shuo Zhu, Jian Ye*, and Li Lin*. "Resonant strategy in designing NIR-II SERS nanotags: a quantitative study." The Journal of Physical Chemistry C, 2022, 126, 12575.

7.   Yao Lu, Li Lin*, Jian Ye*, “Human metabolite detection by surface-enhanced Raman spectroscopy”, Materials Today Bio, 2022, 13, 100205.

8.   Li Lin, Jian Ye, “Spontaneous Raman and Surface-Enhanced Raman Scattering Bioimaging.” In: Wei X., Gu B. (eds) Optical imaging in Human Disease and Biological Research. Advances in Experimental Medicine and Biology, vol 3233. Springer, Singapore, 2021, pp177-195.

9.  Li Lin, Qiang Zhang, Xiyao Li, Meng Qiu, Xin Jiang, Hongchen Gu*, Dang Yuan Lei*, Jian Ye*, “Electron Transfer in Plasmonic Nanogaps Interrogated with Surface-Enhanced Raman Scattering,” ACS Nano, 2018, 12, 6492.