Graduated with a Ph.D. from the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, followed by postdoctoral research at the Biomedical Engineering, Shanghai Jiao Tong University. Joined the Biomedical Engineering Department, Shanghai Jiao Tong University as a research associate in July 2025. Dedicated to research in the side effects caused by antitumor drugs, with the goal of developing adjuvant therapies that can prevent or mitigate these side effects without compromising the efficacy of antitumor treatments. Key research findings have been published in top journals such as Science Translational Medicine.

2019-2022, Shanghai Jiao Tong University, School of Biomedical Engineering, Postdoctoral Fellow

2022-2025, OnQuality Pharmaceuticals, Associate director

July 2025 - Present, Shanghai Jiao Tong University, School of Biomedical Engineering, Assistant Research Fellow

Mechanisms and therapy strategies of side effects induced by antitumor drugs

1. You, Q. ^#, Chen, L.^#, et al. (2024). Topical JAK inhibition ameliorates EGFR inhibitor–induced rash in rodents and humans. Science Translational Medicine 16, eabq7074.
2. Chen, L.^#, You, Q. ^#, et al. (2022). Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy. eLife 11, e72443.
3. Sheng, X.^#, You, Q.^#, Zhu, H. ^#, et al. (2020). Enterohemorrhagic E. coli effector NleL disrupts host NF-κB signaling by targeting multiple host proteins. Journal of Molecular Cell Biology 12, 318-321.
4. Sheng, X.^#, You, Q.^#, et al. (2017). Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK. PLoS Pathogens 13, e1006534.
5. Liu, S., Zeng W., Li, W., You, Q., et al. (2023). OQL025, a topical cream for the prevention of epidermal growth factor receptor inhibitor-induced skin rash. Cancer Research 83, 3211.
6. Wu, C., Fang, K., Zeng W., Li, W., Liu, S., You, Q., et al. (2023). OQL06x, a gut-restricted janus kinase inhibitor to control epidermal growth factor receptor inhibitor-induced diarrhea. Cancer Research 83, 3212.
7. Chen, L., You, Q., et al. (2021). GPCR-mediated EGFR transactivation ameliorates skin toxicities induced by afatinib. Acta Pharmacologica Sinica 43, 1534-1543.
8. Liu, Z. ^#, Li, H. ^#, Hong, C., Chen, M., Yue, T., Chen, C., Wang, Z., You, Q., et al. (2018). ALS-Associated E478G Mutation in Human OPTN (Optineurin) Promotes Inflammation and Induces Neuronal Cell Death. Frontiers in Immunology 9, 2647.
9. Peng, H. ^#, Yang, J. ^#, Li, G., You, Q., et al. (2017). Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress. Cell Research 27, 657-674.