Weiliang XIA


Email : wlxia@sjtu.edu.cn

Office address : 211 Med-X Bldg. (Xuhui)


Weiliang Xia, Ph.D., is currently Professor at School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University. He is also Associate Dean of Zhiyuan College, an Honors College at SJTU.  Dr. Xia obtained his doctoral degree from the University of Hong Kong with predoctoral training at the Rockefeller University in New York City from 2003-2006, followed by a postdoctoral fellowship at the University of California, San Francisco from 2007 to 2008. He joined SJTU by the end of 2008. The research interest of his group includes mechanisms of cancer progression, treatment resistance and theranostic target identification, exosome biology and application, roles of FGF/FGFR signaling and sirtuins in cancer progression and tissue repair. Dr. Xia has published more than 100 research papers since 2005, which have been cited over 6000 times with an H-index of 38. He has been awarded the Rising Star Prize by Shanghai Science and Technology Commission, SMC and Tang Lixin Young Faculty Award of SJTU. He is funded by National Natural Science Foundation of China and Ministry of Science and Technology. He is also a member of Youth Working Committee for the Chinese Cell Biology Society, and a member of American Association for Cancer Research.

Education background

2002-2006 PhD in Molecular and Cell Biology, The University of Hong Kong with joint pre-doctoral program at The Rockefeller University

1999-2002 BSc in Biotechnology, The University of Hong Kong

1998-1999 Enrolled and studied in the BSc Program in Biology and Biotechnology,Dept. of Biological Science and Biotechnology, Tsinghua University

Work Experience

2014-present Professor, School of Biomedical Engineering, Shanghai Jiao Tong University

2012-2014 Special Investigator (Tenure-track Associate Professor), School of Biomedical Engineering, Shanghai Jiao Tong University

2008-2011 Associate Professor, Med-X Research Institute, Shanghai Jiao Tong University 

2007-2008 Postdoctoral Associates, University of California at San Francisco

Areas of Research Interests

Mechanisms of lung/prostate cancer progression and treatment resistance, and discovery of novel targets; biology of exosome and applications; role of FGF/FGFR and sirtuin in cancer and tissue repair.

Honors And Awards

“Rising Star” Award (2009), Science and Technology Commission of Shanghai

SMC Award (2009), Shanghai Jiao Tong University

First Prize in Teaching Achievement (2013), Shanghai Jiao Tong University

Second Prize in Teaching Achievement (2013), Shanghai Municipality

Tang Lixin Scholar (2018), Shanghai Jiao Tong University

Grand Prize in Teaching Achievement (2020), Shanghai Jiao Tong University

Boards, Advisory Committees, Professional Organizations

Member, American Association for Cancer Research; 

Member, Chinese Cell Biology Society; 

Member, Chinese Biomedical Engineering Society.


Cell Biology, BI277 (Spring, School of Biomedical Engineering)

Cell Biology, MS202 (Autumn, honors course for Zhiyuan College)

Cell Biology Tutorials, BI260 (Autumn, Zhiyuan College)

ZIRC Exploratory Laboratory Course, MS126 (Autumn/Spring, Zhiyuan College)

Selected Publications
  1. Li F, Li Z, Han Q, Chen Y, Ji W, Yang Y, Lu S, Xia W*. Enhanced autocrine FGF19/FGFR4 signaling drives the progression of lung squamous cell carcinoma, which responds to mTOR inhibitor AZD2104. Oncogene. 2020; 37:3507–3521.
  2. Li F, Li X, Li Z, Ji W, Lu S, Xia W*. βKlotho is identified as a target for theranostics in non-small cell lung cancer. Theranostics. 2019; 9:7474-7489.
  3. Cheng Y, Zeng Q, Han Q, Xia W*. Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes. Protein Cell. 2019; 10:295-299. 
  4. Wang K, Ji W, Yu Y, Li Z, Niu X, Xia W*, Lu S*. FGFR1-ERK1/2-SOX2 axis promotes cell proliferation, epithelial-mesenchymal transition, and metastasis in FGFR1-amplified lung cancer. Oncogene. 2018; 37:5340-5354. 
  5. Lu T, Li Z, Yang Y, Ji W, Yu Y, Niu X, Zeng Q, Xia W*, Lu S*. The Hippo/YAP1 pathway interacts with FGFR1 signaling to maintain stemness in lung cancer. Cancer Lett. 2018; 423:36-46.
  6. Shao J, Yang X, Liu T, Zhang T, Xie QR, Xia W*. Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal cell death. Protein Cell. 2016, 7:281-290.
  7. Chen Y, Gu H*, Zhang DS, Li F, Liu T, Xia W*.Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrier. Biomaterials. 2014;35:10058-10069.