Associate professor

Email : xiongliqin@sjtu.edu.cn

Office address : 207 Med-X Research Institute (Xu Hui)

Website : https://bme.sjtu.edu.cn/Web/FacultyDetail/84


Dr. Liqin Xiong is an Associate Professor of School of Biomedical Engineering, Shanghai Jiao Tong University. She received the bachelor’s degree (2004) in Chemistry and Life Science from Gannan Normal University, the master’s degree (2007) in Chemistry from Beijing Normal University, and the doctoral degree in Chemistry from Fudan University in July 2010. Dr. Xiong conducted postdoctoral research at Stanford University School of Medicine for period August 2010 to July 2012. She has published over 40 papers with h-index 19 and citation times over 3000. Dr. Xiong has won the Dow Chemical Scholarship in 2009, Shanghai Pujiang Talent Program in 2013, and Li Lanxin Young Teacher Award in 2016. She instructs the course Molecular Imaging and Early Disease Detection for undergraduate students and the course Molecular Imaging and Probe for graduated students.

Her main research focus is to develop novel molecular imaging nanoprobes and techniques for non-invasive detection of cancer and its metastasis at the earliest stage. The techniques developed in her research will allow a close examination of the molecular, metabolic and physiological characteristics of cancers and their responses to therapy. In order to achieve this goal, her lab is aimed to develop novel nanoprobes, and validate new strategies for high throughput screening.

Education background

PhD in Inorganic Chemistry (2007-2010), Department of Chemistry, Fudan University, Shanghai, China

MS in Organic Chemistry (2004-2007), College of Chemistry, Beijing Normal University, Beijing, China

BS in Chemistry (Minor in biology) (2000-2004), School of Chemistry and Chemical Engineering, Gannan Normal University, Jiangxi, China

Work Experience

Postdoctoral Fellow (2010-2012), Molecular Imaging Program at Stanford, Department of Radiology, Stanford University, California, USA.

Associate Professor (2012-Present), School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China

Areas of Research Interests

Smart nanoprobes and Tumor Molecular Imaging

Lymphatic System Imaging

Brown Adipose Tissue Imaging

Uptake, metabolism and toxicity of nanoprobes in animals and plants

Honors And Awards

Li Lanxin Young Teacher Award (2016)

“Shanghai Pujiang Talent” Program (2013)

Shanghai Teaching Achievement Award (Second Prize, 2013)

Academic Star (2010)

Outstanding Graduate Student (2010)

Fudan “Self-Dependence” Scholarship for Academic Research (2010)

Dow Chemical Scholarship (2009)

Boards, Advisory Committees, Professional Organizations

Member of Biomedical Photonics Committee of Chinese Optical Society (2015-present)


Undergraduate Courses:

Molecular Imaging Technology and Probe- BI309 (Aut)

Graduate Courses:

Molecular Imaging and Early Disease Detection- X082002 (Aut)

Research Projects

1. NSFC (PI: Xiong LQ)

81974273 (2020.01-2023.12)

Multi-modal multi-scale imaging the structure and function of the lymphatic vessels in vivo based on fluorescent polymer dots

2. NSFC (PI: Xiong LQ)

8167070220 (2017.01-2020.12)

The design and study of multi-color fluorescent/photoacoustic polymer nanoprobes for precise diagnosis of lymph node metastasis in lung cancer

3. NSFC (PI: Xiong LQ)

81301261 (2014.1-2016.12)

The design of novel PET/NIRF dual-modal nanoprobes and tumor-targeted imaging studies

4. NSFC (PI: Xiong LQ)

21374059 (2014.1-2015.12)

The design and application of folate receptor targeted near-infrared fluorescent conjugated polymer nanoparticles

Selected Publications
  1. Zhang Y, Li Y, Tang S, Li X, Guan W, Li X, Li Y, Zhang C, Xiong L*. Modified polymer dots for multi-scale multi-modal imaging of lymphatic system in tumor pre-metastasis. Applied Materials Today, 2020,21,100863.
  2. Yang Y, Zhou D, Zhang Y, Zhang C, Tang S, Guo Y, Ma F*, Yang Y*, Xiong L*. NIR/photoacoustic imaging of multitype gallbladder cancer using carboxyl/amino functionalized polymer dots. Biomater Sci. 2020;8(23):6657-6669.
  3. Zhou D, Yang Y, Jin L, Yang Y, Wang S, Cai Q, Guan W*, Ma F*, Xiong L*. Near-Infrared Polymer Dots in the Portal-Hepatic Circulation Achieve Localization of Hepatic Carcinoma In Vivo. ACS Appl. Bio Mater. 2020, 3, 6177−6186.
  4. Li Y, Yang Y, Tang S, Zhang Y, Li X, Guan W, Ma F, Zhang F, Xiong L*. High-Resolution Imaging of the Lymphatic Vascular System in Living Mice/Rats Using Dual-Modal Polymer Dots. ACS Appl. Bio Mater. 2019, 2, 3877−3885.
  5. Zhang Y, Li Y, Guo Y, Yang Y, Tang S, Xiong L*, Fluorescent Polymer Dots for Tracking SKOV3 Cells in Living Mice with Probe-Based Confocal Laser Endomicroscopy, Mol Imaging Biol 2019;21:1026-33.
  6. Li J, Li Y, Tang S, Zhang Y, Zhang J, Li Y, Xiong L*. Toxicity, uptake and transport mechanisms of dual-modal polymer dots in penny grass (Hydrocotyle vulgaris L.). Environmental Pollution, 2020;265:114877.
  7. Zhang J, Teng F, Tang S, Zhang Y, Guo Y, Li J, Li Y, Zhang C, Xiong L*. The Effect of Polymer Dots During Mammalian Early Embryo Development and Their Biocompatibility on Maternal Health. Macromol. Biosci. 2020, 2000128.
  8. Guo Y, Li Y, Yang Y, Tang S, Zhang Y, Xiong L*. Multiscale Imaging of Brown Adipose Tissue in Living Mice/Rats with Fluorescent Polymer Dots. ACS Appl. Mater. Interfaces, 2018;10:20884-96.
  9. Cao F, Guo Y, Li Y, Tang S, Yang Y, Yang H, Xiong L*. Fast and Accurate Imaging of Lymph Node Metastasis with Multifunctional Near-Infrared Polymer Dots. Adv. Funct. Mater. 2018;28(16):1707174.
  10. Xiong L, Shuhendler AJ, Rao J*. Self-luminescing BRET-FRET near-infrared dots for in vivo lymph-node mapping and tumour imaging. Nat Commun. 2012;3:1193.

1. Xiong, Liqin; Cao, Fengwen; Conjugated polymer-based nanoprobe and preparation method and application thereof, US 10702612.

2. Xiong, Liqin; Cao, Fengwen; A kind of conjugated polymer nano probe and its preparation method and application, Faming Zhuanli Shenqing (2018), CN 108653751 A 20181016.

3. Xiong, Liqin; Cao, Fengwen; Conjugated polymer nanometer probe and preparation method and application therefor, PCT Int. Appl. (2018), WO 2018176699 A1 20181004.  

4. Zhang, Juxiang; Tang, Shiyi; Xiong, Liqin; A kind of fluorescent conjugated polymer nano probe in peripheral neurotoxicity imaging application of, Faming Zhuanli Shenqing (2020), CN 112007173 A 20201201.

5. Li, Jingru; Xiong, Liqin; Fluorescent conjugated polymer nanoparticles for improving photosynthesis of green plants and preparation method thereof, Faming Zhuanli Shenqing (2020), CN 111484695 A 20200804.