Phone number : 021-62933629

Email : lil@sjtu.edu.cn

Office address : 502 Med-X Bldg. (Xuhui)


Dr. Li Li is a professor and PhD supervisor in School of Biomedical Engineering. He focused on the important roles and mechanism of epigenetic regulatory factors in a variety of physiological and pathological processes. He systematically studied and elucidated the mechanism of epigenetic regulatory factors in diseases and development, which provided reliable targets and theoretical basis for clinical diagnosis and treatment of these diseases.

He has published more than 40 SCI papers in Nat Genet, Cancer Cell,,Nat Cell BiolGutHepatology, Nat Commun, Genes Dev, PNAS, et al, including 23 papers as first or corresponding author (IF > 270). He is the memeber of editorial board of Bosnian J basic Med and a special reviewer of Cancer Letters and Transl Oncol.

Education background

1995-1999 Bachelor - Peking University

1999-2005 Ph.D. – Beijing Institute of Radiation Medicine

Work Experience

Assistant professor in Beijing Insititute of Biotechnology (2005 - 2008).

Post-doctoral research scientist in University of Oxford (2009 - 2011).

Associate professor in Chinese Academy of Sciences (2012 - 2015).

Areas of Research Interests

Tumorigenesis, development related diseases and intervention,

Stem cells for organ repair,


Animal Model of Human Diseases.

Honors And Awards

First prize of Beijing science and technology award, (2017);

Boards, Advisory Committees, Professional Organizations

memeber of editorial board of Bosnian J basic Med


Molecular and Nano Medical Engineering

Animal Models of Human Disease


Research Projects

2 State Projects For Essential Drug Research and Development

4 grants from NSFC (Youth Fund Project and General Project)

3 grants from the Science and Technology Commission of Shanghai Municipality

Selected Publications

1. Liu C, Li X, Zhu Y, Feng W, Zhang W, Ma C, Xu Y, Gui Liming, Aji R, Gao WQ, Li L*. SETD2 deficiency promotes renal 1 fibrosis through the TGF-β/Smad signaling pathway in the absence of VHL. (*Corresponding author, In preparation)

2. Ding Z#, Cai T#, Sun H, Qi X, Zhang Y, Ji Y, Yuan L, Chang H, Ma Y, Zhou H, Li L*, Sheng H*, Qiu J*. Setd2 supports GATA3+ST2+ thymic-1 derived Tregs and suppresses intestinal inflammation. (*Co-corresponding author, Nat. Commun., IF: 17.694, accepted)

3. Chang J, Ji X, Deng T, Qiu J, Ding Z, Li Z, Ma Y, Hu X, Li L*, Qiu J*. Setd2 determines distinct properties of intestinal ILC3 subsets to regulate intestinal immunity. Cell Rep., 2022, 38(11): 110530. (*Co-corresponding author, 9.995)

4. Chen Y, Liu M, Wang W, Li L*, Lin GN*. Loss of Setd2 associates with aberrant microRNA expression and contributes to inflammatory bowel disease progression in mice. Genomics, 2021, 113(4): 2441-54. (*Co-corresponding author)

5. Liu M, Rao H, Liu J, Li X, Feng W, Gui L, Tang H, Xu J, Gao WQ*, Li L*. The Histone Methyltransferase SETD2 Modulates Oxidative Stress to Attenuate Experimental Colitis. Redox Biol., 2021, 43: 102004. (*Co-corresponding author, IF: 10.787)

6. Rao H, Li X, Liu M, Liu J, Feng W, Tang H, Xu J, Gao WQ*, Li L*. Multi-level regulation of β-catenin activity by SETD2 suppresses the transition from polycystic kidney disease to clear cell renal cell carcinoma. Cancer Res., 2021, . (*Co-corresponding author, IF: 13.312)

7. Li X, Liu C, Zhu Y, Rao H, Liu M, Gui L, Feng W, Tang H, Xu J, Gao WQ, Li L*. Setd2 Epidermal Deficiency Promotes Cutaneous Wound Healing via Activation of AKT/mTOR Signaling. Cell Proliferat., 2021, . (*Corresponding author, IF: 8.755)

8. Li Y#, Tang H#*, Chen F#, Chen J, Wang H, Chen Z, Duan Y, Wang X, Li L*, Ouyang K*. SETD2 is essential for terminal differentiation and enucleation of erythroblasts during fetal erythropoiesis. Biochem. Bioph. Res. Co., 2021, 552: 98-105. (*Co-corresponding author)

9. Chen F, Chen J, Wang H, Tang H, Li Y, Huang L, Wang X, Fang X, Liu J, Li L*, Ouyang K*, Han Z*. Histone lysine methyltransferase SETD2 regulates coronary vascular development in embryonic mouse hearts. Front. Cell Dev. Biol., 2021; 9: 651655. (*Co-corresponding author)

10.Wang W, Zhao J, Song W, Li L* and Lin GN*. Alternatively splicing interactomes identify RPL10 as a novel isoform-specific partner for NSD2. Front. Cell Dev. Biol., 2021; 9: 612019. (*Co-corresponding author)

11.Li XJ, Li QL, Ju LG, Zhao C, Zhao LS, Du JW, Wang Y, Zheng L, Song BL, Li LY, Li L*, Wu M*. Deficiency of Histone Methyltransferase SET Domain-Containing 2 in Liver Leads to Abnormal Lipid Metabolism and HCC. Hepatology, 2021, 73(5): 1797-815. (*Co-corresponding author, 17.298)

12.Liu J#, Feng W#, Liu M, Rao H, Li X, Teng Y, Yang X, Xu J, Gao WQ, Li L*. Stomach-specific c-Myc overexpression drives gastric adenoma in mice through AKT/mTOR signaling. Bosnian J Basic Med., 2020, . (*Corresponding author)

13.Rao H#, Li X#, Liu M, Liu J, Li X, Xu J, Li L*, Gao WQ*. Di-Ras2 Promotes Renal Cell Carcinoma Formation by Activating the Mitogen-Activated Protein Kinase Pathway in the Absence of von Hippel-Lindau. Oncogene, 2020, 39(19): 3853-66. (*Co-corresponding author, IF: 8.756)

14.Niu N#, Lu P#, Yang Y, He R, Zhang L, Shi J, Wu J, Yang M, Zhang ZG, Wang LW, Gao WQ, Habtezion A, Xiao GG, Sun YW*, Li L*, Xue J*. Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia-mesenchymal transition during pancreatic carcinogenesis. Gut, 2020, 69(4): 715-26. (*Co-corresponding author, IF: 31.793)

15.Liu M#, Sun T#, Li N, Peng J, Fu D, Li W, Li L*, Gao WQ*. BRG1 Attenuates Colonic Inflammation and Tumorigenesis through Autophagy-dependent Oxidative Stress Sequestration. Nat. Commun., 2019, 10(1): 4614. (*Co-corresponding author, IF: 17.694)

16.Ji Z, Sheng Y, Miao J, Li X, Zhao H, Wang J, Cheng C, Wang X, Liu K, Xu L, Yao J, Shen L, Hou J, Zhou W, Sun J*, Li L*, Gao WQ*, Zhu HH*. The histone methyltransferase Setd2 is indispensable for V(D)J recombination. Nat. Commun., 2019, 10(1): 3353. (*Co-corresponding author, IF: 17.694)

17.Xu Q#, Xiang Y#, Wang Q#, Wang L#, Bogutz AB, Zhang Y, Zhang B, Yu G, Xia W, Du Z, Huang C, Ma J, Zheng H, Li Y, Liu C, Jonasch E, Lefebvre L, Wu M, Lorincz MC, Li W*, Li L*, Xie W*. SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development. Nat. Genet., 2019, 51(5): 844-56. (*Co-corresponding author, IF: 41.307)

18.Wang L#, Niu N#, Li L#, Shao R, Ouyang H, Zou W*. H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells. PLoS Biol., 2018, 16(11): e2006522. (#Co-1st author, IF: 9.593)

19.Zuo X#, Rong B#, Li L#, Lv R, Lan F*, Tong MH*. The histone methyltransferase Setd2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice. J Biol. Chem., 2018, 293(24): 9188-97. (#Co-1st author)

20.Sun L, Li B, Su X, Chen G, Li Y, Yu L, Li L*, Wei W*. A Ursolic Acid-derived Small Molecule Triggers Cancer Cell Death Through Hyperstimulation of Macropinocytosis. J Med. Chem., 2017, 60(15): 6638-48. (*Co-corresponding author, IF: 8.039)

21.Shi Y, Sun L, Chen G, Zheng D, Li L*, Wei W*. A combination of the telomerase inhibitor, BIBR1532, and taxol synergistically inhibit cell proliferation in breast cancer cell lines. Target. Oncol., 2015, 10(4): 565-73. (*Co-corresponding author)

22.Li L#, Wang D#, Xue M#, Mi X, Liang Y, Wang P*. 3'UTR shortening identifies high-risk prostate cancers with targeted dysregulation of ceRNA netwok. Sci. Rep., 2014, 4: 5406. (#Co-1st author) 

23.Mould A#, Morgan MA#, Li L#, Bikoff EK, Robertson EJ*. Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta. Genes Dev., 2012, 26(18): 2063-74. (#Co-1st author, IF: 12.890)

24.Li L#, Deng B#, Xing G, Teng Y, Tian C, Cheng X, Yin X, Yang J, Gao X, Zhu Y, Zhang L*, Yang X*, He F*. PACT is a negative regulator of p53 and essential for cell growth and embryonic development. Proc. Natl. Acad. Sci. USA., 2007, 104(19): 7951-6. [Comment: PACT regulates p53 controlled network of genes. Proc. Natl. Acad. Sci. USA., In this issue, 2007, 104(19): 7731-2] (#Co-1st author, IF: 12.779) 

25.Yuan H, Han Y, Wang X, Li N, Liu Q, Yin Y, Wang H, Pan L, Li L, Song K, Qiu T, Pan Q, Chen Q, Zhang G, Zang Y, Tan M, Zhang J, Li Q, Wang X, Jiang J, Qin J. SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways. Cancer Cell., 2020, 38(3): 350-65.e7.

26.Tian C, Xing G, Xie P, Lu K, Nie J, Wang J, Li L, Gao M, Zhang L*, He F*. KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Nat. Cell Biol., 2009, 11(5): 580-91.

27.Lu K#, Yin X#, Weng T, Xi S, Li L, Xing G, Cheng X, Yang X, Zhang L*, He F*. Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1. Nat. Cell Biol., 2008, 10(8): 994-1002.